Immune system mucosa forms special immunological memory read more at here www.spinonews.com/index.php/item/857-immune-system-mucosa-forms-special-immunological-memory

If a vaccine is to protect the intestines and other mucous membranes in the body, it also needs to be given through the mucosa. The mucosa forms a unique immunological antibody memory that does not occur if the vaccine is given by injection.

Immunological memory is the secret to human protection against various diseases and the success of vaccines. It allows our immune system to quickly recognize and neutralize threats.

Mats Bemark, associate professor of immunology at Sahlgrenska Academy, University of Gothenburg says, the largest part of the immune system is in our mucosa. Even so, we understand less about how immunological memory protects us there than we do about protection in the rest of the body.

Researchers show that the mucosal immune system can lead to a lifelong memory in the intestines of mice. After immunization, long-lived cells make antibodies that are transported into the intestine through the mucosa. In addition, memory cells form that can rapidly initiate a new immune response if needed and that can form new cells that produce antibodies.

Researchers show that the memory cells created in the mucosa are different from memory cells formed in other parts of the body. And a bit surprisingly, it seems that the cells that make antibodies in the mucosa and the memory cells in the mucosa are not created at the same time.

The study shows that, it is possible to achieve an immunological antibody memory with mucosal vaccination and that the memory cells that are created in connection with this type of vaccination are unique and cannot be achieved through traditional vaccination methods. This means that only mucosal vaccinations can provide immunological protection in the mucosa.

For the study, the research team used a new method in which mice were immunized with a model vaccine that is given orally. The researchers could follow the cells formed during the immune response for the rest of the mouse's life.